School of Medicine - Basic Medical SciencePhysiology I

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生理学Ⅰトップ

Our core competence is to investigate properties of cortical neurons, including channel functions and synaptic plasticity, by using electrophysiological methods. We have so far elucidated novel modes of channel coupling that constitute negative or positive feedback regulations of neuronal excitability. Interestingly, some of these regulation mechanisms are reasonably related with the pathophysiology of major depression and Alzheimer’s disease. By relying on molecular biological methods as well, we started collecting evidence that could link neurophysiological and behavioral variables in the context of these neuropsychiatric disorders, so as to find out new vistas of yet unknown therapeutics.

Contact Information

TEL: 076-218-8102 / FAX: 076-286-3523 / Email: physiol1@kanazawa-med.ac.jp(教室)  kato@kanazawa-med.ac.jp(加藤)

Faculty

Professor

  • KATO Nobuo 6

Senior Assistant Professor

  • ONO Munenori
  • TAJIMA Nobuyoshi
  • YAMAMOTO Ryo

Research Fellow

  • XU Feng
  • MA LanLan

Research Achievements

Research Activities

  • Zhang Y, Wang F, Luo X, Wang L, Sun P, Wang M, Jiang Y, Zou J, Uchiumi O, Yamamoto R, Sugai T, Yamamoto K, Kato N. (2015) Cognitive improvement by photic stimulation in a mouse model of Alzheimer’s disease. Curr Alzheimer Res 12: 860-869.
  • Wang F, Zhang Y, Wang L, Sun P, Luo X, Ishigaki Y, Sugai T, Yamamoto R, Kato N. (2015) Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice. Neuropharmacology 97: 210-219.
  • Wang L, Kang H, Li Y, Shui Y, Yamamoto R, Sugai T, Kato N. (2015) Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer’s disease. Neuropharmacology 92: 8-15.
  • Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N. Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with Homer1a. Journal of Neuroscience 31:11100-11109, 2011.
  • Sun P, Wang F, Zhang Y, Zhang Q, Wang L, Yamamoto R., Sugai T, Wang Z, Kato N. Increase in cortical pyramidal cell excitability accompanies depression-like behavior in mice: a transcranial magnetic stimulation study. Journal of Neuroscience 31:16464-16472, 2011.

External Research Funding